Mechanism of down regulation of luteinizing hormone receptors and steroidogenesis in corpora lutea
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چکیده
منابع مشابه
Effect of luteinizing hormone on progestin levels in rabbit corpora lutea.
Rabbits were injected intravenously with luteinizing hormone (lh) or saline solution on Day 9 of pseudopregnancy and killed \m=1/2\,24 or 48 hr later. Corpora lutea of lh-treated animals had decreased significantly in size and progesterone content at 24 and 48 hr compared to corpora lutea of control rabbits. Luteal content and concentration of 20\g=a\-hydroxypregn-4-en-3-onewere increased at \m...
متن کاملDown-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for L...
متن کاملIsolation of the luteinizing hormone-chorionic gonadotropin receptor in high yield from bovine corpora lutea. Molecular assembly and oligomeric nature.
The luteinizing hormone-human chorionic gonadotropin (LH-hCG) receptor was isolated from 8-liter batches of a supernatant (7,000 X g) of bovine corpora lutea homogenate from 1,200 ovaries obtained biweekly from the Wampole Laboratories, Princeton, NJ. The supernatant was concentrated by ultrafiltration to remove an inhibitor of hormone-receptor binding and inert proteins of M, < 50,000. The con...
متن کاملAggregation of luteinizing hormone receptors in granulosa cells: a possible mechanism of desensitization to the hormone.
The temporal relationship between redistribution of receptors to lutropin (luteinizing hormone)/human chorionic gonadotropin in cultured rat ovarian granulosa cells and the cellular response to hormonal challenge were studied. Visualization of receptor-bound human chorionic gonadotropin by indirect immunofluorescence, with hormone-specific antibodies after fixation with 2% formaldehyde, reveale...
متن کاملHormonal regulation of connexin-43 in baboon corpora lutea.
The synthesis and secretion of progesterone in the corpus luteum are regulated by both endocrine and paracrine/ autocrine factors which affect the steroidogenic cells. Evidence suggests that these cells communicate via cell-cell junctional proteins, the connexins. Previously we have shown that connexin-43 is expressed in both human and baboon (Papio hamadryus anubis) corpora lutea, with differe...
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ژورنال
عنوان ژورنال: Journal of Biosciences
سال: 1988
ISSN: 0250-5991,0973-7138
DOI: 10.1007/bf02712153